PURE PDGF
The next generation of growth factor.
Bringing the power of pure PDGF+ to the aesthetics space.
Nature’s
rejuvenating protein.
PDGF-BB is one of the most conserved proteins in nature. Without naturally existing PDGF we wouldn’t be alive. Following any disruptive skin procedure, our body naturally releases PDGF at the site of the disruption and helps promote skin rejuvenation.
PDGF-BB is:
- Released from the body’s own platelets in response to soft tissue and bone damage
- Highly conserved in mammals
- The only proven growth factor that safely replicates your body’s natural ability to rejuvenate your skin
We use recombinant technology to produce a sterile, pharmaceutical-grade PDGF-BB product.
A high-quality and consistent product,
every time.
Recombinant human rhPDGF–BB is a potent, sterile, consistent, off-the-shelf form of platelet-derived growth factor.
- Made utilizing recombinant engineering to modify yeast, enabling the production of specific proteins or biological products by inserting a gene of interest into the yeast’s DNA
- Purified to ensure consistency and sterility
- Widely used in industries such as pharmaceutical, healthcare, and agriculture, allowing for the efficient and scalable creation of proteins
01 YEAST
02 STERILE BIOREACTOR
03 PURIFICATION
04 PURE PDGF
Recombinant technology—Manufactured according to exacting scientific standards to ensure every lot is pure, potent, consistent, and sterile to safely rejuvenate your patient’s skin. This incredible potency means results may be obtained with fewer applications, leaving you with happier clients.
Pharmaceutical-grade, pure PDGF. No human cell components. No variance in potency. Every time.
The most consistent concentration of growth factors in aesthetics
Recombinant technology ensures purity and consistent potency, with up to 300,000 times more concentration vs. PRP and exosomes—in every application.
ariessence eliminates the purity risk of exosomes on microneedled or laser treated skin. You never know the provenance of exosomes nor the growth factor levels of your patient’s PRP. ariessence contains only four (4) ingredients whereas exosomes contain an unknown number of components!
pure PDGF is predictable every time, and sterile, with a well-documented safety profile, resulting in enhanced outcomes. No other growth factor can match pure PDGF’s record of safety and credibility.
The broad benefits of pure PDGF vs other aesthetic-based alternatives
pure PDGF+ vs. exosomes vs. PRP vs. Polydeoxyribonucleotides
pure PDGF+
This table reflects general characteristics of different aesthetic product types based on published research and technical reports. FDA approval of PDGF applies only to certain medical products and indications unrelated to cosmetic use. ariessence pure PDGF+® is intended for topical cosmetic use only.
FDA approval of these products was based on each product’s own formulation, controls, extensive safety and effectiveness data, including data derived from blinded, randomized, controlled human clinical trials (i.e., pivotal studies) which were conducted independently from ariessence pure PDGF+®.
Trust the science.
Believe in the results.
pure PDGF+ has up to 300,000x the concentration of growth factor versus PRP, PRF†,‡
Kobayashi E, Flückiger L, Fujioka-Kobayashi M, Sawada K, Sculean A, Schaller B, Miron RJ. Comparative release of growth factors from PRP, PRF, and advanced-PRF. Clin Oral Investig. 2016 Dec;20(9):2353-2360. doi: 10.1007/s00784-016-1719-1. Epub 2016 Jan 25. PMID: 26809431.
Data on file, LRM Aesthetics.
An origin steeped in scientific excellence
Dr. Samuel Lynch, The World’s Leading Authority on growth factors
Dr. Lynch learned the value of hard work while growing up in rural poverty on a small family farm in southern Illinois. Through his determination, he was accepted into a post-doctoral program at Harvard, where he received dual degrees before beginning a long and rewarding career in regenerative medicine.
Dr. Lynch is…
- A pioneering researcher
- An innovator in applied science, with over 150 patents and 120 publications
- An entrepreneur with four successful companies built & sold
Today Dr. Lynch is credited with identifying therapeutic applications for platelet-derived growth factor, a discovery that has benefitted millions of patients. In an effort to bring rigorous scientific and clinical, evidence-based products to the aesthetics space, Dr. Lynch founded LRM Aesthetics.
Dr. Lynch is among the most influential and accomplished figures in the field of growth factor medicine research and application
Dr. Lynch's Origin Story
Growth from
growth factor legacy
LRM Aesthetics is an advanced skin care company aiming to revolutionize skin care, through scientific excellence. Our first product, ariessence pure PDGF+, is the purest, most highly concentrated PDGF product ever available to the aesthetics market.
pure PDGF-BB was discovered and developed by Harvard Scientist Samuel Lynch, DMSc, DMD and colleagues. It is the culmination of more than 30 years of research and innovative applied science by Dr Lynch, who is founder and CEO of LRM Aesthetics, Inc., and an internationally renowned innovator in regenerative medicine.
Proven
over decades
PDGF is one of the most researched growth factors in medicine. It is proven to be safe, effective and has been studied in more than 1000 publications and 100+ clinical studies.
Regranex®
1997
GEM 21S®
2005
Augment®
2015
Augment® Injectable
2018
Four separate medical products containing recombinant rhPDGF-BB approved by the Food and Drug Administration (FDA) have been successfully used to treat over 5.5 million patients in the last 28 yrs*.
LRM Aesthetics brings proven science and excellence to skin rejuvenation.
FDA approval of these products was based on each product’s own formulation, controls, extensive safety and effectiveness data, including data derived from blinded, randomized, controlled human clinical trials (i.e., pivotal studies) which were conducted independently from ariessence pure PDGF+®.
Leading the evolution of skin care technology
1970s
Platelet-Rich Plasma (PRP) is first used
The term platelet-rich plasma (PRP) was first used in the 1970s to describe plasma with a platelet count above that of peripheral blood. PRP contains growth factors naturally found in platelets, delivering 3-6x the growth factor concentration of normal blood. However, the PRP in a patient’s blood is determined by their age and overall health, making it difficult to get a consistent output.
1980s
Exosomes are first discovered
Exosomes, which are tiny packages (vesicles) that cells use to communicate with one another, are discovered. Exosomes contain growth factors, but it’s unknown if these growth factors reach a therapeutic concentration. In addition, exosomes can be low in purity, may come from unknown human sources, and may be contaminated with other proteins.
1990s
Recombinant rhPDGF-BB research
begins to show value
Signaling a new generation of skin rejuvenation, rhPDGF-BB starts to be used in research, followed by FDA approvals for different medical products. Since then, over 5.5 million patients have been treated with rhPDGF-BB.*
2024
LRM Aesthetics launches
ariessence pure PDGF+®
LRM Aesthetics has developed a method for large-scale manufacturing of a proprietary form of the body’s most important protein that promotes skin rejuvenation: ariessence pure PDGF+. This revolutionary product delivers the purest, most highly concentrated PDGF-BB available in a cosmetic, helping to support skin rejuvenation.
FDA approval of these products was based on each product’s own formulation, controls, extensive safety and effectiveness data, including data derived from blinded, randomized, controlled human clinical trials (i.e., pivotal studies) which were conducted independently from ariessence pure PDGF+®.
Purity you can trust.
Natural-looking skin they can see and feel.
In the aesthetics market, no post-aesthetic procedure product enables the level of time-tested success that is possible with pure PDGF+. If you’re looking to add a PURE, POTENT, PREDICTABLE, and PROVEN approach to skin rejuvenation to your practice, look no further than ariessence pure PDGF+.
Order Now